Sifting and culling through the combined works of Charles Sanders Peirce, Karl Pribram, William John, Calvin Sowa, Stuart Hameroff, Manfred Clynes and others well known in the domain of neuroscience, logic, mathematics and philosophy, the author, John D. Norseen puts forth a staggering set of principles for the onset of the era of Sentient Behavior in Machines. Using mathematics as the formation of what he calls semiotic reality, he describes emergent mathematical properties of information interacting with neural structures – the results of which we call thought. Norseen does a masterful job of describing this basic construct analogous to the Bernoulli’s equations of airflow over an airfoil producing lift. He calls such an emergent process of biochemical induced, electromagnetic E & H field mediated interaction of information with uniquely configured neural structures, and expressed into work via protein reconfiguration, under the term BioFusion. And he does an equally good job of putting forth examples of how Biofusion and the Russian work in Reflexive Control can be used for the development of the first generation of Sentient Machines, for which Norseen has a patent pending. From semiotics, to brain mapping, to concepts for information operations in both cyberspace and the biosphere, Norseen even explores the concept of the human condition as a steganographic ‘biomark’ capable of recording and playback in Krylov Space.